Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
Identifieur interne : 000214 ( 2020/Analysis ); précédent : 000213; suivant : 000215Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
Auteurs : Junwen Luan [République populaire de Chine] ; Yue Lu [République populaire de Chine] ; Xiaolu Jin [République populaire de Chine] ; Leiliang Zhang [République populaire de Chine]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2020.
Abstract
SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and
Url:
DOI: 10.1016/j.bbrc.2020.03.047
PubMed: 32201080
PubMed Central: 7102515
Affiliations:
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first="Leiliang" last="Zhang">Leiliang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32201080</idno><idno type="pmc">7102515</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102515</idno><idno type="RBID">PMC:7102515</idno><idno type="doi">10.1016/j.bbrc.2020.03.047</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" 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sort="Luan, Junwen" uniqKey="Luan J" first="Junwen" last="Luan">Junwen Luan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Yue" sort="Lu, Yue" uniqKey="Lu Y" first="Yue" last="Lu">Yue Lu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Xiaolu" sort="Jin, Xiaolu" uniqKey="Jin X" first="Xiaolu" last="Jin">Xiaolu Jin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Leiliang" sort="Zhang, Leiliang" uniqKey="Zhang L" first="Leiliang" last="Zhang">Leiliang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochemical and Biophysical Research Communications</title><idno type="ISSN">0006-291X</idno><idno type="eISSN">1090-2104</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and <italic>Circetidae</italic> mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N. Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. 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Qin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Luan, Junwen" sort="Luan, Junwen" uniqKey="Luan J" first="Junwen" last="Luan">Junwen Luan</name></noRegion><name sortKey="Jin, Xiaolu" sort="Jin, Xiaolu" uniqKey="Jin X" first="Xiaolu" last="Jin">Xiaolu Jin</name><name sortKey="Jin, Xiaolu" sort="Jin, Xiaolu" uniqKey="Jin X" first="Xiaolu" last="Jin">Xiaolu Jin</name><name sortKey="Lu, Yue" sort="Lu, Yue" uniqKey="Lu Y" first="Yue" last="Lu">Yue Lu</name><name sortKey="Lu, Yue" sort="Lu, Yue" uniqKey="Lu Y" first="Yue" last="Lu">Yue Lu</name><name sortKey="Zhang, Leiliang" sort="Zhang, Leiliang" uniqKey="Zhang L" first="Leiliang" last="Zhang">Leiliang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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